منابع مشابه
Protein Structure Prediction in Genomics
As the number of completely sequenced genomes rapidly increases, including now the complete Human Genome sequence, the post-genomic problems of genome-scale protein structure determination and the issue of gene function identification become ever more pressing. In fact, these problems can be seen as interrelated in that experimentally determining or predicting or the structure of proteins encod...
متن کاملProtein structure prediction and structural genomics.
Genome sequencing projects are producing linear amino acid sequences, but full understanding of the biological role of these proteins will require knowledge of their structure and function. Although experimental structure determination methods are providing high-resolution structure information about a subset of the proteins, computational structure prediction methods will provide valuable info...
متن کاملThe role of protein structure in genomics.
The genome projects produce an enormous amount of sequence data that needs to be annotated in terms of molecular structure and biological function. These tasks have triggered additional initiatives like structural genomics. The intention is to determine as many protein structures as possible, in the most efficient way, and to exploit the solved structures for the assignment of biological functi...
متن کاملComparative Protein Structure Modeling in Genomics
The function of a protein is generally determined by its three-dimensional (3D) structure. Thus, it would be useful to know 3D structure of the thousands of protein sequences that are emerging from the many genome projects. This is the aim of structural genomics. The aim will be achieved by a focused, large-scale determination of protein structures by X-ray crystallography and nuclear magnetic ...
متن کاملIn Silico Prediction and Docking of Tertiary Structure of Multifunctional Protein X of Hepatitis B Virus
Hepatitis B virus (HBV) infection is a universal health problem and may result into acute, fulminant, chronic hepatitis liver cirrhosis, or hepatocellular carcinoma. Sequence for protein X of HBV was retrieved from Uniprot database. ProtParam from ExPAsy server was used to investigate the physicochemical properties of the protein. Homology modeling was carried out using Phyre2 server, and refin...
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ژورنال
عنوان ژورنال: Briefings in Bioinformatics
سال: 2001
ISSN: 1467-5463,1477-4054
DOI: 10.1093/bib/2.2.111